The strain and its metabolites are identified . the results show that the culture has a broad antimicrobial spectrum against some gram - negative and gram - positive bacteria , and moulds , especially against e . coli , bacillus cereus , and staphylococcus aureus 研究证实，分离出的r21 - 4具有广谱抗菌作用，对革兰氏阴性菌、革兰氏阳性菌、真菌都有一定的拮抗作用，特别是对大肠杆菌、金黄色葡萄球菌、蜡状芽孢杆菌抗菌作用较强。
The results showed that the extract by etoac presented a significant effect on staphylococcus aureau 、 bacillus cereus 、 bacillus megateriurn 、 proteus species , corynebacterium pekinense 、 trichoderma viride and aspergillus flavus all of which belonged to bacteria ; the extract by n - buoh presented significant inhibitory effect on bacillus mesentericus , bacillus subtilis 、 proteus species 、 bacterium prodigious , trichoderma viride and aspergillus flavus all of which belonged to bacterium ; the inhibitory effect become stronger and stronger with the extract concentration increaseing and the water phase of the extract did not present any antimicrobial effects 结果表明，乙酸乙酯萃取物对细菌中的金黄色葡萄球菌、蜡状芽孢杆菌、变形杆菌、巨大芽孢杆菌、北京棒状杆菌和霉菌中的绿色木霉、黄曲霉有明显的抑菌作用；正丁醇萃取物对细菌中的马铃薯芽孢杆菌、变形杆菌、枯草芽孢杆菌、灵杆菌和霉菌中的绿色木霉以及黄曲霉有明显的抑菌作用，且提取物的抑菌作用随浓度增大而增强，而水相则没有抑菌活性。
The main research contents and results are as follows : ( 1 ) disc papers and oxford cups were used to ascertain bacteriostatic effect of hongqu . using 70 % ethanol and water as solvent , the extraction inhibited bacillus subtilis , bacillus cereus and staphylococcus aureus and had no effect on e . coli , salmonella . typhi , yeasts and algae 主要研究内容和结果如下： ( 1 )利用滤纸片法和管碟法确定了红曲的抑菌谱：红曲70乙醇和水溶液浸提物对蜡样芽孢杆菌、枯草芽孢杆菌等革兰氏阳性菌具有较强的抑制作用，对革兰氏阴性菌、霉菌和酵母菌没有抑制效果。
